Dnmt3a Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comDnmt3a Polyclonal Antibody for Rat(Rattus norvegicus)

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Index > Protein center > Dnmt3a(Gene name) > Rat

Dnmt3a (Gene name),

DNA (cytosine-5)-methyltransferase 3A (Protein name ), DNM3A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Dnmt3a;

Protein name:

DNA (cytosine-5)-methyltransferase 3A(Dnmt3a);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L) (By similarity). Interacts with DNMT1 and DNMT3B. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD domain (By similarity). Interacts with the PRC2/EED-EZH2 complex (By similarity). Interacts with UBC9, PIAS1 and PIAS2.

Function:

Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

Subcellular Location:

Nucleus Cytoplasm

Protein Attributes:

Sequence length:

908

Sequence:

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908:

LKEYFACV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q1LZ53

UniGene:

Rn.92659

SMR:

Q1LZ53

Pfam:

PF00145

KEGG:

rno:444984

Uniprot:

Q1LZ53

FOR

ELISA Kit for Rat Dnmt3a

Cat.:

E13889h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Rat Dnmt3a

Cat.:

E13889r

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MSDS:

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Packing:

96T

ELISA Kit for Rat Dnmt3a

Cat.:

E13889m

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MSDS:

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Packing:

96T

ELISA Kit for Rat Dnmt3a

Cat.:

E13889c

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Dnmt3a

Cat.:

U13889m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Dnmt3a

Cat.:

U13889r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Dnmt3a

Cat.:

U13889h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Dnmt3a

Cat.:

U13889c

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Dnmt3a

Cat.:

P13889Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Dnmt3a

Cat.:

P13889Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Dnmt3a

Cat.:

P13889Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Dnmt3a

Protein for Rat Dnmt3a

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci."
Lees-Murdock D.J. , McLoughlin G.A. , McDaid J.R. , Quinn L.M. , O'Doherty A. , Hiripi L. , Hack C.J. , Walsh C.P.
Genomics84:193-204(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)

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